Description: Recombinant Human IL-17(IL-17A)Product SpecificationsExpression of Human Proteins in Human CellsExtreme low EndotoxinHigh PurityAnimal Free and Xeno FreeTag FreeSource: Human cells derivedStructure: Glycosylated monomerPurity: >95% by SDS-PAGEEndotoxin Level: <0.5EU/ugMolecular Weight: 30-35kDaFormulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier proteinActivity AssayThe activity was measured by its ability to induce IL-6 expression in the NHDF adult fibroblasts.ReconstitutionBriefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.Stability & StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.Protein DescriptionIL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17(IL-17A) is a homodimer of two 136 amino acid chains that are secreted by activated T cells. IL-17A is expressed by activated Th17 cells. IL-17A induces stromal cells to produce proinflammatory and hematopoietic cytokines. It also enhances the surface expression of ICAM1 (intracellular adhesion molecule 1) in fibroblasts.ReferencesBettelli E, et al. (2008) Nature 453,1051-1057.Cua DJ, et al. (2010) Nat. Rev. Immunol. 10, 479.Fossiez F, et al. (1996) J. Exp. Med. 183, 2593-2603..
Price: 49.99 USD
Location: Livermore, California
End Time: 2025-01-08T21:10:52.000Z
Shipping Cost: 11 USD
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Item Specifics
All returns accepted: ReturnsNotAccepted
Brand: StemImmune LLC
Unit Type: Unit
Volume/Quantity: 10ug/vial
Custom Bundle: No
Model: HIM-I17a-0010
MPN: HIM-I17a-0010
Country/Region of Manufacture: United States
Unit Quantity: 10ug/vial
Intended Use/Discipline: Anesthesiology, Biological Laboratory, Cardiology, Cosmetology, Dental Laboratory, Dentistry, Dermatology, Emergency Medicine, Endocrinology, Endodontics
